Excess (hyperuricemia, hyperuricemia) or shortage (hipourisemia, hyporuricemia) plasma uric acid levels in the blood is often an indication of a disease or disorder in the human body.
In humans, uric acid is a product of purine nucleotide catabolism last track, because the absence of urikase enzyme that converts uric acid into allantoin. Excessive levels of uric acid can cause kidney stones and / or gout in the joints.
Gout.
Gout is the result of excessive consumption of purine substances. Purines into uric acid is processed body, but if excess uric acid levels, so the kidneys are unable to remove uric acid crystals accumulate in the joints. As a result, joint pain, swollen and inflamed.Uric acid is a disease of purine metabolic waste substances originating from the rest of the food we eat. Purine itself is a substance contained in each food derived from living bodies. In other words, in the living body are purine substance, and then because we eat living beings, then the purine substances move into our bodies. A variety of vegetables and fruits also contained purines. Purine also resulted from the destruction of body cells which occur normally or because of certain diseases. Usually gout attack in the elderly, because the accumulation of these purine material.
Abstinence gout sufferers.
- Offal:
brain, lungs, liver, spleen, intestines, kidneys and tripe.- Seafood (seafood):
shrimp, crab, squid, octopus, clams, cuttlefish, mussels, oysters, anchovies, sardines.- Riverfood (Food river):
catfish, eel, shrimp, crabs and snails.- Extract the meat.
such as shredded and jerky.- Food that has been canned.
(example: corned beef, sardines, beef and pork).- Meat.
mutton, dog meat, pork, beef, buffalo meat and horse meat.- Poultry.
Ducks, geese and turkeys.- Birds and bats.
- Nuts.
soybeans (including processed products such as tempeh, tofu, tauco, oncom, soy milk), peanuts, green beans, bean sprouts and chips melinjo.- Vegetables.
cauliflower, spinach, asparagus, beans, mushroom, leaves of cassava / sweet potato, papaya, spinach and chilli / chilli.- Cream.
ice cream and broth or gravy is thick.- Certain fruits such as durian, pineapple and coconut water.
- Foods that are fried or cooked using coconut milk or margarine / butter.
- Foods rich in protein, fat and blood.
Additional tips for people with gout.
- Consumption of foods containing high potassium such as tomatoes, potatoes, yogurt and bananas.- Consumption of fruit that contains vitamin C, such as oranges, papaya and strawberries.
Examples of fruit and vegetables to treat gout: dragon fruit, starfruit, ginger, pumpkin, mustard greens, chicory, lemon grass and tomato.
- Increase consumption of complex carbohydrates such as rice, cassava / sweet potato and bread.
- Reduce consumption of simple carbohydrates such as type of fructose sugar, candy, cotton candy, cotton candy and syrup.
- Do not take aspirin.
- Do not work too hard / fatigue.
- In people who are overweight (obesity), usually uric acid levels quickly rose but spending a little bit, then you should lose weight with exercise.
- Adjust energy intake with the body's needs, based on height and weight.
To cure this disease there are several things that must be done, including :
- Avoid foods that can increase uric acid, such as offal (liver, kidney, spleen, tripe, intestines, lungs and brain), avoid seafood (shrimp, scallops, squid, crab); canned food (corned beef, sardines and meat extracts), broth or gravy is thick.- Avoid foods such as chips, kale and spinach, cassava leaves / sweet potatoes, leaf cashew nuts, asparagus, beans and cauliflower. Avoid nuts (peanuts, green beans, soybeans, tempe, tauco, bean sprouts, oncom) and soy milk.
- Avoid eating durian, avocado, pineapple, coconut water.
- The food is safe to eat, some of which are: rice, fish fins and scales, chicken, eggs, cheese, milk and some fruits.
- Avoid alcoholic beverages and food.
- In obese people, uric acid is usually increased while spending less, then for security, people are usually advised to lose weight.
- Drink plenty of water at least 8-10 glasses per day, due to drink plenty of water, we can help dispose of purines in the body.
Risk factor.
Some risk factors that can cause a person to have high levels of uric acid in the body are:
- Lifestyle.
Consumption of foods high in purines, alcohol consumption, can increase uric acid levels in the blood.- Medical Condition.
Medical conditions such as high blood pressure, diabetes, hypercholesterolemia, often associated with cases of gout.- Drugs.
The use of drugs such as diuretics, aspirin should be considered and consulted a doctor because it can increase uric acid levels.- Genetic.
Some people who have a family history of gout history is also one risk factor.- Age and Gender.
Men have a greater risk of developing inflammatory disorders because of gout, but women who have entered menopause are also at risk as much as men.Ascorbic acid.
Ascorbic acid is a chemical compound called vitamin C, in addition to dehydroascorbic acid. He shaped whitish yellow crystalline powder soluble in water and has antioxidant properties. Ascorbic name is derived from the root word a- (without) and scorbutus (skurvi), a disease caused by a deficiency of vitamin C. In 1937, the Nobel Prize in chemistry awarded to Walter Haworth for his work in determining the chemical structure of ascorbic acid. At the time of its discovery in the 1920s, he called heksuronat acid by some researchers.In general, the cell nucleus of eukaryotic cells with concentrations of ascorbic acid are much more concentrated, which is absorbed through the transporter SVCT1 or / and SVCT2, compared with a concentration in erythrocytes and concentration in blood plasma. For example in plasma or erythrocyte concentrations around 40-80 μM, concentrations of ascorbic acid in the cytoplasm of lymphocytes can reach 4 mM. Among mammals, humans have a ratio smaller plasma ascorbic acid and uric acid is higher, because of genetic mutations with L-gulonolakton oxidase expression and urikase.
Ascorbic acid is an antioxidant amazing that protect cells from stress extracellular, with an increase in the proliferation of endothelial cells, stimulating the synthesis of collagen type IV, the degradation of LDL oxidation, inhibiting atherosclerosis and stress intracellular by maintaining levels of α-tocopherol in erythrocytes and neurons, and protect hepatocytes from oxidative stress caused by exposure to allyl alcohol. The antioxidant properties derived from the hydroxyl group of a C number 2 and 3 were donated H + ion together with electrons leading to a variety of compounds with a free radical oxidants such as oxygen or nitrogen group, peroxide and superoxide. Nevertheless, in the cytoplasm with high concentrations of Fe compounds, ascorbic acid can be pro-oxidant because redox reactions of Fe3 + to Fe2 + which triggers the compound superoxide and ultimately become free radicals highly reactive hydroxyl groups. Vasodilation / constriction of blood vessels that are generally caused by the decrease of NO secretion by endothelial cells can also be muted ascorbic acid by increasing the secretion of NO by endothelial cells through the path of NO synthase or cyclase guanilat, mengreduksi nitrita becomes NO, and inhibit LDL oxidation.
Ascorbic acid also plays a very important role as a coenzyme and an electron donor in organic reactions such dioxygenase enzymatic hydroxylation on carnitine, EGF; or mono- and di-oxygenation in the synthesis of various neurotransmitters and peptide hormones, noradrenaline, cholesterol and amino acids; demethylation of histone and nucleic acids; dealkylation Oxidative DNA; improve the quality of succinic acid, malic acid and glycerol 3-phosphate in the mitochondria; proton homeostasis force; deglikanasi proteoglycan compound; ROS excess catch to decrease oxidative stress. One function very well known cofactor is hydroxylase prolil and lisil that mengkopling hydroxylated in hypoxia-inducible factor-1α and procollagen.
Therefore capacity as antioxidants that reduce reactive oxygen species that can cause hypertension, ascorbic acid is often considered to be high blood pressure. A study showed that ascorbic acid can reduce the ratio of plasma C-reactive protein, 8-isoprostanes, and malondialdehyde-modified LDL, though not always accompanied by a decrease in blood pressure.
Ascorbic acid is also used as an anti-cancer therapy in certain species because of the pressing nature of cytokines IL-18 and hyaluronidase enzyme in the degradation of hyaluronic acid to prevent metastasis, stimulation of collagen to isolate the tumor cells in vivo, preventing the effects of oncogenic viruses, and carcinogens. Ascorbic acid is known to be toxic to several types of cancer cells, but not be so against the body's normal cells. Clinical studies showed that administration of high doses of vitamin C, either through injection or intake, can relieve simtoma pathogens and extend the life expectancy of patients with advanced cancer, such as RCC, bladder tumors, lymphoma B cells
Thank you for reading this article. Written and posted by Bambang Sunarno. sunarnobambang86@gmail.com
author:
https://plus.google.com/105319704331231770941.
name: Bambang Sunarno.
http://primadonablog.blogspot.com/2015/09/do-you-know-about-gout.html
DatePublished: 13 September 2015 11:28
Tag : About Gout.
Code : 7MHPNPADAEFW
These are very helpful tips for me and thanks for sharing. To reduce uric acid the best way is taking gout dietary supplements.
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